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Epithalon

Also known as: Epitalon, Epithalamin, AEDG Peptide

Research Only

Molecular Formula

C14 H22 N4 O9

Molecular Weight

390.35 Da

Half-Life

5–6 minutes

Sequence

H-Ala-Glu-Asp-Gly-OH

Clinical Applications & Evidence

Mechanism of Action

Operates as a pleiotropic signaling molecule. It upregulates hTERT expression to activate telomerase; binds to specific histones (e.g., H1.3) to induce pericentromeric structural heterochromatin decondensation; stimulates the pineal-endocrine axis for melatonin secretion; and activates the Nrf2 pathway to enhance superoxide dismutase (SOD) production.

Investigated Uses

  • Telomere elongation and cellular rejuvenation
  • Circadian rhythm normalization
  • Retinal degenerative disease (retinitis pigmentosa)
  • Immune system restoration in aging
  • Neuroendocrine regulation
Moderate Clinical Data

Regulatory & Safety Status

FDA Status

Research Only

WADA / Athletic Status

Prohibited in Competition

Known Side Effects

Injection site irritationDrowsinessGenerally well-tolerated in studies

Contraindications

  • Active malignancy (theoretical telomerase concern)
  • Pregnancy

Drug Interactions

  • May interact with melatonin supplements
  • Caution with immunomodulators

Citations & Clinical Trials

PubMed Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties SSRP Institute FDA Announces Change in Status of 12 Peptides Alzheimer's Drug Discovery Foundation Epithalamin and Epithalon — Cognitive Vitality For Researchers