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Selank

Also known as: TP-7

Research Only

Molecular Formula

C33 H57 N11 O9

Molecular Weight

751.87 Da

Half-Life

2–3 minutes

Sequence

Thr-Lys-Pro-Arg-Pro-Gly-Pro

Clinical Applications & Evidence

Mechanism of Action

Positive allosteric modulation of GABA-A receptors, specific inhibition of enkephalin-degrading carboxypeptidases, rapid elevation of BDNF expression in the hippocampus, and targeted immunomodulation via suppression of pro-inflammatory cytokines such as IL-6.

Investigated Uses

  • Generalized anxiety disorder
  • Cognitive enhancement and memory
  • Immune modulation
  • Neurasthenia and adjustment disorders
  • Adjunct in PTSD and depression research
Moderate Clinical Data

Regulatory & Safety Status

FDA Status

Research Only

WADA / Athletic Status

Prohibited in Competition

Known Side Effects

Nasal irritationMild fatigue (rare)Generally well-tolerated

Contraindications

  • Pregnancy
  • Known allergy to tuftsin derivatives

Drug Interactions

  • May potentiate anxiolytic medications
  • Caution with immunosuppressants

Citations & Clinical Trials

PubMed Selank Anxiolytic Properties — Preclinical Review