Semax
Also known as: ACTH(4-7)-PGP, Heptapeptide Semax
Molecular Formula
Molecular Weight
813.92 Da
Half-Life
1–2 hours (plasma elimination); biological efficacy persists up to 24 hours
Sequence
Met-Glu-His-Phe-Pro-Gly-Pro
Clinical Applications & Evidence
Mechanism of Action
Semax initiates a pleiotropic neurobiological cascade. It significantly upregulates the mRNA expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), alongside their respective Trk receptors. Concurrently, the peptide modulates the dopaminergic and serotonergic neurotransmitter systems to enhance executive function and mood. During ischemic or traumatic neural events, Semax exerts a 'transcriptomic compensation effect,' actively suppressing pro-inflammatory cytokine and apoptotic genes (MMP-9, c-Fos, JNK) while simultaneously activating genes responsible for neurotransmission and vascular repair. Additionally, Semax exhibits anti-amyloidogenic properties by strongly chelating copper (Cu²⁺) ions, thereby inhibiting amyloid-beta fibrillogenesis.
Investigated Uses
- Cognitive enhancement and memory
- Ischemic stroke recovery (approved in Russia)
- ADHD and attention disorders
- Optic nerve disease
- Neuroprotection in neurodegeneration
Regulatory & Safety Status
FDA Status
Research OnlyWADA / Athletic Status
Prohibited in CompetitionKnown Side Effects
Contraindications
- Pregnancy
- Acute psychosis
- Known allergy to ACTH derivatives
Drug Interactions
- May potentiate stimulant medications
- Synergistic with Selank